Is juvenile rheumatoid arthritis/juvenile idiopathic arthritis different from rheumatoid arthritis?
نویسندگان
چکیده
Historical background Rheumatologists have long known that the common chronic arthropathies of childhood have both similarities and differences from adult-onset rheumatoid arthritis (RA), although it is also recognized that a few patients with typical RA will present in childhood. Arthritis in children is more heterogeneous than RA, and just as in RA, the pathological basis for juvenile arthritis is being explored with molecular techniques. In his 1966 Heberden oration, Professor Eric Bywaters noted among his conclusions that every child has their own disease [1]. This truism is correct, but a great many similarities in pathophysiology between children with the same clinical phenotypes are increasingly being defined. These features, including genetic markers, are different in many respects from the adult counterparts, although, overall, there are gross similarities (Table 1). This paper explores these similarities and differences in childhood arthritis compared with adult disease.
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1 Minden K, Niewerth M, Listing J et al. Long-term outcome in patients with juvenile idiopathic arthritis. Arthritis Rheum 2002;46:2392–401. 2 Hashkes PJ, Laxer RM. Medical treatment of juvenile idiopathic arthritis. J Am Med Assoc 2005;294:1671–84. 3 Cortis E, Insalaco A. Macrophage activation syndrome in juvenile idiopathic arthritis. Acta Paediatr 2006;95(Suppl.):38–41. 4 Cohen SB, Emery P, ...
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